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Technology involving patent rights held by Keio University. For further information, please inquire at the KLL Desk.
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KIF研究プロジェクト
Research Project at Keio Innovation Foundry (KIF) as one of Keio University Faculty of Science and Technology 75th Anniversary Commemorative Project.

Medical-Engineering Collaboration Zone

Keio University has a history of conducting collaborative research between the School of Medicine and the Faculty of Science and Technology. This research has lately expanded beyond the medical field to encompass robotics, cognitive science, and even big data. The exhibit will highlight leading technologies being developed by this medical-engineering collaboration at Keio University.
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Medical-Engineering Collaboration Zone
The world’s first! Sleep Stage Extraction Algorithm using only Heart Rate
Professor YASUI, Masato
Department of Pharmacology, Keio University School of Medicine
Associate Professor FUKUNAGA, Koichi
Department of Pulmonary Medicine,
Keio University School of Medicine

ProfessorMITSUKURA, Yasue
Department of System Design Engineering
In this research, we introduce the world’s first device which can accurately determine 5 stages of REM, NonREM 1, 2, 3, Awake simply by measuring heart rate.
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Medical-Engineering Collaboration Zone
Project for Objective Measures by Collaborating Medical and Technology
Assistant Professor KISHIMOTO, Taishiro
Department of Neuropsychiatry, Keio University School of Medicine
ProfessorMITSUKURA, Yasue
Department of System Design Engineering
Mental health issue is glowingly important in many countries. However, due to the lack of biomarkers that closely reflect illness severity, psychiatry field suffers enormously in diagnosing, assessing treatment response, and developing new drugs. We are developing new assessment tools to quantify the severity of psychiatric symptoms utilizing information technology and machine targeting patients’ voice, facial expression, body movement, language, heart rate variability, electro encephalogram, language, daily activity, sleep, etc.
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Medical-Engineering Collaboration Zone
Integrated development of probes and microscope for bioimaging
Associate Professor NURIYA, Mutsuo
Department of Pharmacology, Keio University School of Medicine
ProfessorFUJIMOTO, Yukari
Department of Chemistry
The first step in characterizing the action of drugs and bioactive molecules is to visualize them. In general, however, such visualizations are difficult because these molecules are not visible and tissues are not transparent. Here, we will introduce a new approach to overcome these difficulties by integrated development of probes and microscope.
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Medical-Engineering Collaboration Zone
Multifunctional Gene Delivery System For rAAV-mediated Gene Transfer Using Hydrogel Microparticles
Assistant Professor FUJIOKA, Masato
Department of Otorhinolaryngology,
Keio University School of Medicine

Associate ProfessorONOE, Hiroaki
Department of Mechanical Engineering
Over 500 million people in the world are annoyed with hearing loss and biomedical scientists have been developing gene therapies for the deafness. We are trying to generate new methods efficiently introduce genes into the inner ear to support those therapeutics by utilizing multifunctional hydrogel-based microparticles.
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Medical-Engineering Collaboration Zone
Glycomics for diagnosis and drug discovery in metastatic prostate cancer
Professor OYA, Mototsugu
Department of Urology, Keio University School of Medicine
ProfessorSATO, Toshinori
Department of Biosciences and Informatics
The number of patients with prostate cancer is increasing rapidly, and the mortality rate in male cancer will be ranked first in the near future. Although organ confined prostate cancer has become curable, treatment outcome for metastatic prostate cancer is limited. In this study, in order to deepen the understanding of drug resistance, we are conducting glycomics of drug resistant prostate cancer cells.
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Medical-Engineering Collaboration Zone
Surface-engineered substrate for large-scale human iPS cell culture
Professor FUKUDA, Keiichi
Department of Cardiology, Keio University School of Medicine
Associate ProfessorMIYATA, Shogo
Department of Mechanical Engineering
Large scale culture of human induced pluripotent stem cells (hiPSCs) is an essential technique for clinical application. We will introduce the surface modifying technology to succeed in reducing matrix coating and providing optimal culture condition for hiPSCs.
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